Spermidine is a naturally occurring polyamine that plays a role in cellular growth, repair, and protection. It supports autophagy — the body’s natural process of removing damaged cells — and contributes to mitochondrial function and longevity pathways. Higher levels are often linked to improved cellular renewal and resilience against oxidative stress. Low levels may indicate decreased cell turnover, nutritional deficiencies, or increased oxidative stress.
Spermidine is a naturally occurring polyamine that supports cellular growth, repair, and protection. It promotes autophagy – the body’s process of clearing damaged cells – and contributes to mitochondrial efficiency, metabolic balance, and longevity pathways.
Spermidine levels are affected by diet, gut microbial activity, and metabolic health. Natural sources include foods like wheat germ, soybeans, mushrooms, and aged cheese, while oxidative stress, aging, and nutrient deficiencies can reduce levels.
Testing can be beneficial for those interested in longevity, cellular health, or maintaining oxidative stress balance. It may also help detect impaired autophagy or decreased metabolic resilience.
Yes. A nutrient-rich diet, adequate sleep, physical activity, and supporting gut microbial diversity all help sustain healthy spermidine production. Reducing oxidative stress and maintaining balanced polyamine metabolism further promote optimal cellular renewal.