Primary Bile Acids (CA, CDCA)
Primary bile acids – cholic acid (CA) and chenodeoxycholic acid (CDCA) – are produced in the liver and represent the first step in bile acid metabolism. They are essential for emulsifying dietary fats and enabling the absorption of fat-soluble vitamins. Elevated levels can indicate altered bile acid synthesis or cholestasis, while low levels may suggest reduced hepatic production or bile flow. Balanced concentrations reflect normal liver function and bile acid turnover.
Description
Increased levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) may indicate impaired bile acid flow, cholestasis, or disrupted hepatic metabolism. Elevated concentrations can also result from inflammation, toxins, or hormonal imbalances affecting liver function.
Testing can be useful for people experiencing digestive discomfort after fatty meals, bloating, or nausea, as well as those suspected of having liver or gallbladder problems. It can also offer insights into fat-soluble vitamin absorption and overall bile acid metabolism.
Levels depend on liver synthesis, bile flow, microbial metabolism, and intestinal reabsorption. Hormonal changes, diet composition, medications, and gut dysbiosis can all impact bile acid balance and recycling.
Yes. Supporting liver and gallbladder health through proper hydration, fiber, and nutrient intake (especially choline, taurine, and antioxidants) helps promote normal bile synthesis and flow. Regular physical activity and maintaining gut microbial balance also contribute to optimizing bile acid turnover.
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