NOTCH1 (Notch Receptor 1): NOTCH1 is a critical component of the Notch signaling pathway, which plays a vital role in determining cell fate, maintaining stem cells, and guiding differentiation during both embryonic and adult tissue development. Dysregulation of NOTCH1 signaling is associated with various disorders, including several cancers such as T-cell acute lymphoblastic leukemia, as well as developmental defects. Its wide-ranging impact on cell proliferation and differentiation makes NOTCH1 a key focus in developmental biology and cancer research.
