Indolpropionic acid (IPA) is a microbial metabolite derived from the amino acid tryptophan. It is recognized for its antioxidant properties and contributes to protecting gut barrier integrity and regulating glucose metabolism. Elevated levels are typically linked to a balanced gut microbiota and a healthy intestinal environment. Low concentrations may suggest reduced microbial diversity, altered tryptophan metabolism, or increased oxidative stress.
Low IPA levels may indicate reduced microbial diversity, disrupted tryptophan metabolism, or increased oxidative stress. This could be linked to weakened gut barrier function, heightened inflammation, or changes in glucose regulation.
Testing IPA is beneficial for individuals focused on gut health, antioxidant levels, or metabolic balance. It offers valuable insights for those experiencing digestive problems, chronic fatigue, insulin resistance, or inflammation.
IPA production depends largely on gut microbiota composition and dietary tryptophan availability. A low-fiber diet, dysbiosis, inflammation, or oxidative stress can reduce IPA formation. Conversely, a diverse and balanced gut flora supports its synthesis.
Yes. Supporting microbial diversity through a fiber-rich diet, fermented foods, and antioxidant intake can promote healthy IPA production. Reducing inflammation and maintaining balanced tryptophan metabolism also help sustain optimal levels.