Name: DNA Pharmacogenetics (PGx)
Brand: GetTested
SKU: DNAPX
Price: 199.99 USD
Availability: InStock
Rating: NaN (100 reviews)

ABCG2 (ATP-Binding Cassette Subfamily G Member 2): ABCG2 encodes a protein involved in cellular transport processes. It is a member of the ATP-binding cassette (ABC) transporter family and is responsible for the efflux of various molecules, including drugs and toxins, out of cells. ABCG2 plays a role in drug resistance and the protection of tissues from harmful substances....

ABCG2

SLCO1B1, also known as Solute Carrier Organic Anion Transporter Family Member 1B1, is a membrane-bound transporter protein primarily found in the liver. It plays a crucial role in the uptake of various endogenous and exogenous compounds, including bile acids, hormones, drugs, and toxins, from the bloodstream into hepatocytes (liver cells). One of the primary functions of SLCO1B1 is its involvement in the hepatic uptake of bile acids, a process essential for bile acid homeostasis and bile formation. By transporting bile acids across the sinusoidal membrane of hepatocytes, SLCO1B1 facilitates their clearance from the bloodstream and their subsequent incorporation into bile, which...


SLCO1B1

CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9): CYP2C9 is a key enzyme in the cytochrome P450 enzyme family, responsible for the metabolism of various drugs and endogenous compounds. It plays a significant role in the detoxification and clearance of substances in the liver. Genetic variations in CYP2C9 can affect drug metabolism, influencing drug efficacy and toxicity, and are important considerations in personalized medicine for determining appropriate drug dosages for individual patients....

CYP2C9

CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2): CYP4F2 is part of the cytochrome P450 family, involved in metabolizing fatty acids, drugs, and toxins. It plays a role in vitamin K and eicosanoid metabolism, affecting blood clotting and inflammation processes. Genetic variations in CYP4F2 can influence responses to certain medications, especially anticoagulants....

CYP4F2

MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is a key enzyme involved in folate metabolism and the regulation of homocysteine levels in the body. This enzyme catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a crucial step in the remethylation of homocysteine to methionine. Methionine serves as a precursor for S-adenosylmethionine (SAM), a methyl donor essential for numerous methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. Variants in the MTHFR gene, particularly the C677T and A1298C polymorphisms, have been associated with altered enzyme activity and folate metabolism. These variants can lead to elevated homocysteine levels and reduced availability of methyl...


MTHFR

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DNA Pharmacogenetics (PGx)

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DNA Pharmacogenetics (PGx)

Tested genes

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