TYMS
The TYMS gene encodes thymidylate synthase, a crucial enzyme involved in the production of thymidine, one of the four nucleotides necessary for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to function effectively, closely linking TYMS to folate metabolism. Variants in the TYMS gene can influence folate availability at the cellular level and may affect how the body responds to folate or folate-based treatments. These changes can contribute to disrupted DNA synthesis, increased risk of certain diseases, or varied responses to chemotherapy or supplementation.
Description
TYMS encodes thymidylate synthase, an enzyme essential for producing thymidine used in DNA synthesis and repair.
The enzyme uses active folate as a cofactor, so folate levels significantly affect TYMS activity.
Certain variants can decrease enzyme efficiency, affecting DNA replication and folate use.
Yes, they can affect vulnerability to disease or the success of folate-related treatments, including specific chemotherapy drugs.
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