TRMT6, also known as tRNA methyltransferase 6 homolog, is an enzyme that highlights the role of post-transcriptional modification in transfer RNA (tRNA). TRMT6 is part of the class I-like SAM (S-adenosylmethionine)-dependent methyltransferase superfamily and catalyzes the methylation of specific nucleotides within tRNA molecules. This modification, especially at the wobble position of adenosine residues, is essential for accurate and efficient translation of mRNA into protein, helping stabilize codon-anticodon interactions and ensuring fidelity during protein synthesis.