Secondary bile acids

Secondary bile acids are produced in the colon through bacterial modification of primary bile acids originally made in the liver. While they contribute to digestion and microbial balance, high levels may indicate dysbiosis, excessive fat consumption, or disrupted bile acid metabolism. Certain secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), have been linked to mucosal irritation, inflammation, and a heightened risk of colorectal conditions when levels remain elevated. Testing their presence in stool aids in evaluating gut microbial activity and bile detoxification.

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Description

What are secondary bile acids?

They are bile acids produced by intestinal bacteria from primary bile acids that originate in the liver.

Why are secondary bile acids measured in stool?

To assess microbial activity, fat digestion, and possible mucosal effects associated with bile acid transformation.

What does high secondary bile acid indicate?

It may indicate dysbiosis, a high-fat diet, or delayed intestinal transit, and could contribute to gut inflammation.

Are all secondary bile acids harmful?

Not necessarily. In small amounts, they help digestion, but chronically high levels may be irritating or cause inflammation.

How can levels of secondary bile acids be influenced?

Diet (especially fat and fiber), microbial composition, and bile acid recycling efficiency all contribute.

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Content
What are secondary bile acids?
Why are secondary bile acids measured in stool?
What does high secondary bile acid indicate?
Are all secondary bile acids harmful?
How can levels of secondary bile acids be influenced?
What are secondary bile acids?
Why are secondary bile acids measured in stool?
What does high secondary bile acid indicate?
Are all secondary bile acids harmful?
How can levels of secondary bile acids be influenced?
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