SDMA (Symmetric Dimethylarginine)
SDMA is a methylated derivative of the amino acid arginine and is primarily excreted by the kidneys. Unlike ADMA, SDMA does not directly inhibit nitric oxide synthase but reflects similar metabolic and renal processes. Elevated SDMA levels can indicate reduced kidney clearance or altered amino acid metabolism. Stable or optimal SDMA values suggest efficient kidney function and normal arginine turnover.
Description
Elevated SDMA levels themselves may not cause noticeable symptoms, but they can indicate reduced kidney function or impaired amino acid metabolism. Individuals might experience fatigue, fluid retention, or other signs related to decreased renal clearance.
Testing SDMA is beneficial for anyone looking to evaluate kidney health, especially those with conditions such as hypertension, diabetes, or cardiovascular disease. It is also relevant for individuals on high-protein diets, supplements, or medications that might affect kidney function.
SDMA concentrations are affected by kidney filtration rate, protein turnover, and methylation activity. Reduced renal clearance or increased arginine methylation can raise SDMA levels, while proper hydration and metabolic balance help keep levels stable.
In many cases, supporting kidney and metabolic health can help normalize SDMA. Maintaining proper hydration, managing blood pressure and blood sugar levels, and reducing oxidative stress are essential. A balanced diet and supporting methylation pathways may also contribute to keeping SDMA within a healthy range.
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