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GetTested’s Food Intolerance Test 240 items analyzes IgG4 antibodies for 240 different foods often involved in hypersensitivity reactions. Unlike allergic reactions that are instant, symptoms from food intolerance can occur hours to days later, making it difficult to link to the foods you’ve eaten.

<p>GetTested’s Food Intolerance Test 240 items analyzes IgG4 antibodies for 240 different foods often involved in hypersensitivity reactions. Unlike allergic reactions that are instant, symptoms from food intolerance can occur hours to days later, making it difficult to link to the foods you’ve eaten.</p>

Food Intolerance 240 items

NRP2 (Neuropilin 2): NRP2 is a receptor that plays a key role in angiogenesis and lymphangiogenesis, as well as in neuronal guidance. It interacts with vascular endothelial growth factors and semaphorins, influencing the development of blood vessels and nerves. NRP2 is also involved in cancer progression, particularly in tumor angiogenesis and metastasis, and has important roles in developmental processes.

NRP2

SYCP2L (Synaptonemal Complex Protein 2-Like): SYCP2L is a protein involved in meiosis, playing a crucial role in the formation of the synaptonemal complex. This structure is essential for the pairing and recombination of homologous chromosomes. SYCP2L is important for understanding the mechanisms of genetic recombination and fertility, with potential implications in reproductive biology and related disorders.

SYCP2L

SEMA4B (Semaphorin 4B): SEMA4B is a gene that encodes an enzyme essential for the biosynthesis of selenoproteins, which contain the amino acid selenocysteine. Mainly found in the cytoplasm, SEPHS1 plays a crucial role in selenium metabolism by producing selenophosphate, the activated form of selenium needed for incorporating selenocysteine into proteins. Through this function, SEPHS1 supports the proper synthesis of selenoproteins, which are vital for various cellular processes and overall cell health.

SEMA4B

Fertility Markers

hCG (human chorionic gonadotropin) is a hormone produced by the placenta during pregnancy. It plays a crucial role in supporting the corpus luteum, which produces progesterone to maintain the uterine lining for the developing embryo. hCG also helps prevent the breakdown of the corpus luteum, ensuring continued progesterone production.

Food Intolerances

Sheep's milk intolerance is a condition where the body struggles to digest sheep's milk, causing gastrointestinal symptoms. This intolerance is different from a sheep's milk allergy, which involves an immune response and can lead to more severe reactions. People with sheep's milk intolerance typically experience digestive discomfort after consuming sheep's milk or related products.

Sheep’s milk

DPYSL5 (Dihydropyrimidinase Like 5): DPYSL5 is part of a protein family involved in neurodevelopment, especially in axonal growth and guidance. It contributes to neuronal repair and has been researched for its significance in neurodegenerative diseases.

DPYSL5

CDC5L (Cell Division Cycle 5-Like): CDC5L plays a crucial role in regulating cell cycle progression and pre-mRNA splicing. It is part of a complex responsible for maintaining genomic stability and ensuring proper chromosome segregation during cell division. Mutations or alterations in CDC5L expression can disrupt cell cycle control, leading to cellular abnormalities and potentially contributing to cancer development. Research on CDC5L seeks to clarify its role in cell cycle regulation and its potential implications for cancer therapy.

CDC5L

AQP10 (Aquaporin 10): AQP10 is part of the aquaporin family of water channels, involved in transporting water and small solutes across cell membranes. It is mainly expressed in the intestine and plays a role in water absorption and gastrointestinal function. Although its exact physiological roles are still under investigation, AQP10 likely helps regulate water and electrolyte balance, potentially impacting gastrointestinal health and related disorders.

AQP10

CDH12 (Cadherin 12): CDH12 is a member of the cadherin superfamily, proteins that facilitate cell-to-cell adhesion. It is mainly expressed in the nervous system and plays a crucial role in neural development and connectivity. Changes in CDH12 have been associated with neurodevelopmental disorders due to its impact on brain structure and function.

CDH12

NRSN1 (Neurensin 1): NRSN1 is a neuronal protein that may be involved in synaptic function and plasticity. Although its exact role in the brain is not fully understood, it is thought to help regulate neurotransmitter release and neuronal signaling, potentially affecting learning and memory.

NRSN1

FANCC (Fanconi Anemia Complementation Group C): FANCC is a gene that encodes a protein involved in the Fanconi anemia (FA) pathway, which is crucial for DNA repair and maintaining genomic stability. Mutations in FANCC can cause Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and a higher risk of cancer.

FANCC

Amino Acids

The Omega-6 / Omega-3 Ratio represents the balance between Omega-6 and Omega-3 fatty acids in the diet. This ratio is crucial for health, as an imbalance—particularly a high Omega-6 to Omega-3 ratio—is associated with increased inflammation and a greater risk of chronic diseases.

Omega-6 / Omega-3Ratio

RBFOX1 (RNA Binding Fox-1 Homolog 1): RBFOX1 is an RNA-binding protein that plays a crucial role in regulating alternative splicing. It affects the diversity and function of mRNA transcripts in the nervous system and skeletal muscle. By targeting a broad range of pre-mRNAs, RBFOX1 modulates splicing patterns to control gene expression critical for neuronal development, synaptic function, and muscle cell differentiation. Proper RBFOX1 activity is vital for central nervous system development, and its dysregulation has been associated with neurological disorders such as epilepsy and autism spectrum disorders.

RBFOX1

IL17RA (Interleukin 17 Receptor A): IL17RA is part of the receptor complex for interleukin 17 (IL-17), a cytokine that plays a crucial role in regulating inflammatory and immune responses. IL17RA signaling is vital for defense against extracellular pathogens and is involved in the development of several autoimmune and inflammatory diseases, including psoriasis, rheumatoid arthritis, and ankylosing spondylitis. Targeting IL17RA and the IL-17 pathway is a key focus of ongoing therapeutic research for these conditions.

IL17RA

Other

Chloride is an anion (negatively charged ion) made up of chlorine atoms and is a naturally occurring component in many water sources. It originates from the dissolution of salts containing chloride, such as sodium chloride and calcium chloride, in the Earth's crust. Chloride is commonly found in both freshwater and saltwater, and its concentration can vary depending on geological and environmental factors.

Chloride

MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1): MAP3K1 is a critical element of the MAPK signaling pathway, which controls vital cellular functions such as proliferation, differentiation, and response to stress. Mutations in MAP3K1 may lead to developmental disorders and are linked to various forms of cancer.

MAP3K1

KLRK1 (Killer Cell Lectin Like Receptor K1): KLRK1 is a gene that encodes an activating receptor found on natural killer (NK) cells and some T cells. It plays a crucial role in immune surveillance by recognizing stress-induced ligands on target cells, triggering the elimination of infected or transformed cells. KLRK1 is vital for the body’s defense against viral infections and certain cancers.

KLRK1

KIF1A (Kinesin Family Member 1A): KIF1A is a neuron-specific motor protein essential for axonal transport, a process critical for proper neuron function and survival. KIF1A plays a key role in neural development and maintenance, and mutations in this protein are linked to neurodegenerative diseases and developmental neurological disorders.

KIF1A

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5): MAP4K5 is a gene that encodes a protein involved in the MAP kinase signaling pathway, transmitting signals from the cell surface to the nucleus. It affects cellular responses such as inflammation, stress reactions, and immune regulation, and may contribute to autoimmune disease mechanisms.

MAP4K5

Gouda cheese intolerance is a condition in which individuals have trouble digesting gouda cheese, a type of dairy product. Unlike a gouda cheese allergy, which causes an immune response, this intolerance mainly results in digestive discomfort after eating.

Gouda cheese

CD36 (Cluster of Differentiation 36): CD36 is a multifunctional protein that serves as a receptor for various ligands, including oxidized LDL, fatty acids, and phospholipids. It plays a critical role in fatty acid metabolism, inflammation, and atherogenesis. CD36’s role in lipid metabolism and its impact on cardiovascular diseases and metabolic syndrome make it a significant subject of medical research.

CD36

RAD52 (RAD52 Homolog, DNA Repair Protein): RAD52 is a gene that encodes a protein crucial for repairing DNA double-strand breaks, helping preserve genomic stability. It plays a key role in the homologous recombination repair pathway, which guarantees accurate DNA repair during cell division. Mutations in RAD52 can lead to genomic instability, increasing the risk of cancer and certain inherited disorders.

RAD52

TRPS1 (Tricho-Rhino-Phalangeal Syndrome Type I): TRPS1 is a transcription factor that plays a crucial role in regulating the growth and development of bone, hair, and connective tissue. Mutations in TRPS1 cause Tricho-Rhino-Phalangeal Syndrome, characterized by craniofacial and skeletal abnormalities. Understanding TRPS1’s function is essential for diagnosing and managing this syndrome, with ongoing research focused on its role in tissue development and differentiation.

TRPS1

MCFD2 (Multiple Coagulation Factor Deficiency 2): MCFD2 is a gene that encodes a protein essential for the transport and proper folding of coagulation factors V and VIII, which are critical for blood clotting. Mutations in MCFD2 can lead to combined factor V and VIII deficiency, a rare bleeding disorder, highlighting its important role in hemostasis and the impact of disrupted protein transport on blood clotting.

MCFD2

Allergies

Buckwheat intolerance is a condition where the body struggles to digest buckwheat, causing digestive symptoms. Unlike a buckwheat allergy, which triggers an immune response and can lead to severe reactions, intolerance typically results in gastrointestinal discomfort only.

Buckwheat

HNF4A (Hepatocyte Nuclear Factor 4 Alpha): HNF4A is a gene that plays a crucial role in liver development and function. It encodes a transcription factor responsible for regulating the expression of genes involved in liver formation, glucose metabolism, and lipid metabolism. Mutations in HNF4A can cause metabolic disorders, including maturity-onset diabetes of the young (MODY).

HNF4A

Gliadin intolerance is a condition where individuals have trouble digesting gliadin, a protein found in gluten-containing grains like wheat, barley, and rye. This condition can cause digestive discomfort. Unlike a gliadin allergy, which triggers an immune response and more severe reactions, gliadin intolerance mainly leads to gastrointestinal symptoms after eating gluten-containing foods.

Gliadin

OAT (Ornithine Aminotransferase): OAT is a gene that encodes the ornithine aminotransferase enzyme, which plays a crucial role in the urea cycle. This enzyme catalyzes the conversion of ornithine to citrulline, aiding the body in detoxifying ammonia. Mutations in OAT can interfere with this process, resulting in hyperammonemia — a condition characterized by elevated blood ammonia levels that can impact neurological function.

ERMP1 (Endoplasmic Reticulum Metallo Protease 1): ERMP1 is a gene that encodes a protein involved in the processing and maturation of proteins within the endoplasmic reticulum (ER). It helps maintain protein homeostasis by degrading misfolded or unassembled proteins, supporting proper ER function. ERMP1 plays a role in cellular processes such as immune response and ER-associated degradation (ERAD), and its dysregulation can contribute to diseases like neurodegeneration and cancer.

ERMP1

TMEM116 (Transmembrane Protein 116): TMEM116 is a gene that encodes a transmembrane protein involved in various cellular processes. Although its specific function is still under investigation, TMEM116 is believed to play a role in cellular transport and signaling pathways, including membrane dynamics, vesicle trafficking, and regulation of ion channels. Emerging studies indicate it may contribute to cellular homeostasis and intracellular communication, and dysregulation of TMEM116 could affect multiple physiological processes.

TMEM116

CDH19 (Cadherin 19): CDH19 is part of the cadherin family, essential molecules for cell-to-cell adhesion and tissue integrity. CDH19 plays a key role in the nervous system, supporting neuron-to-neuron interactions and contributing to neural development. It has also been researched in relation to neurodevelopmental disorders, including autism spectrum disorders.

CDH19

Cottage cheese intolerance is a condition where individuals have trouble digesting cottage cheese, a dairy product with a curd-like texture and mild flavor. This intolerance can cause digestive discomfort but is different from a cottage cheese allergy, which triggers an immune response and can lead to more severe reactions. People with this intolerance usually experience gastrointestinal symptoms after eating cottage cheese or dairy products that contain it.

Cottage cheese

Camembert cheese intolerance is a condition where individuals have difficulty digesting Camembert cheese, a soft and creamy cheese with a distinctive flavor. Unlike a Camembert cheese allergy, which triggers an immune response and potentially severe reactions, intolerance mainly causes digestive discomfort after eating Camembert cheese or products containing it.

Camembert

White pine trees are conifers with long, slender needles and can contribute to pollen allergies. Although their pollen is less potent than that of some other trees, it may still cause symptoms in sensitive individuals, especially during peak pollen season in the spring.

White Pine

RPA2 (Replication Protein A2): RPA2 is a subunit of the Replication Protein A (RPA) complex and plays a crucial role in DNA replication, repair, and recombination. RPA2 helps stabilize and protect single-stranded DNA (ssDNA) during replication, preventing degradation and supporting the recruitment of other DNA repair proteins. Through these functions, it ensures an effective DNA damage response and contributes to genomic stability. Additionally, RPA2 participates in other cellular processes, including telomere maintenance and DNA damage checkpoints.

RPA2

RREB1 (Ras Responsive Element Binding Protein 1): RREB1 is a gene that encodes a transcription factor that binds to the Ras-responsive element (RRE). It is involved in regulating gene expression in response to Ras signaling and plays a role in cell growth and proliferation.

RREB1

MFF (Mitochondrial Fission Factor): MFF is a protein that plays a crucial role in mitochondrial dynamics, especially in mitochondrial fission. By recruiting dynamin-related protein 1 (Drp1) to the outer mitochondrial membrane, MFF facilitates mitochondrial division, which is vital for proper mitochondrial distribution, quality control, and energy metabolism. This process supports cell health, growth, and adaptation to metabolic demands. Dysregulation of MFF can impair mitochondrial shape and function, disrupting cellular energy balance and contributing to disease.

Gut Markers

Akkermansia muciniphila is a gut bacterium that helps maintain the intestinal mucosa and a healthy gut lining. It is linked to beneficial metabolic and immune effects and may play a key role in gut health, weight management, and overall well-being.

Akkermansia muciniphila

GALNT3 (Polypeptide N-Acetylgalactosaminyltransferase 3): GALNT3 is a gene that encodes a protein involved in O-linked glycosylation, which attaches N-acetylgalactosamine to proteins. This modification is essential for proper protein function and cell signaling. Mutations in GALNT3 can disrupt calcium and phosphate balance, leading to disorders such as familial tumoral calcinosis.

GALNT3

STXBP5 (Syntaxin Binding Protein 5): STXBP5 is a protein that plays a crucial role in regulating neurotransmitter release at synapses. It interacts with components of the SNARE complex, facilitating vesicle trafficking and exocytosis. STXBP5 is essential for proper synaptic function and has been associated with neurological disorders.

STXBP5

MYH15 (Myosin Heavy Chain 15): MYH15 is a gene that codes for a myosin heavy chain protein, mainly found in skeletal muscle. Myosins are motor proteins crucial for muscle contraction and cell movement. Although the specific functions of MYH15 are still being studied, it may be involved in muscle development and overall muscle function.

MYH15

HSD17B13, also known as Hydroxysteroid 17-beta dehydrogenase 13, is an enzyme mainly located in the liver that plays a role in the metabolism of steroid hormones and fatty acids. It is part of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) family, which catalyzes the conversion between hydroxysteroids and ketosteroids. HSD17B13 is important for fatty acid metabolism, especially in the oxidation of long-chain fatty acids, and is found in peroxisomes—cellular organelles responsible for processing fatty acids. Its enzymatic activity is crucial for converting long-chain fatty acyl-CoAs into 3-ketoacyl-CoAs, supporting healthy liver function and lipid metabolism.

HSD17B13

MCPH1 (Microcephalin 1): MCPH1 is a gene that plays a crucial role in brain development, especially in regulating brain size. It is involved in the DNA damage response and cell cycle regulation. Mutations in MCPH1 can cause microcephaly, underscoring its significant role in neurodevelopment.

MCPH1

Lobster and Pacific squid are seafood delicacies enjoyed by many but can cause allergic reactions in some individuals. These allergies may result in symptoms ranging from mild discomfort to severe, potentially life-threatening reactions. Recognizing and managing allergies to lobster and Pacific squid is important for those at risk.

Lobster/Pacific squid

CNTNAP2, also known as Contactin Associated Protein-Like 2, is a cell adhesion molecule that belongs to the neurexin superfamily. It plays a key role in the development and function of the nervous system, particularly in neuronal migration, axon guidance, synapse formation, and signal transmission. CNTNAP2 is predominantly expressed in the developing nervous system, where it interacts with other cell adhesion molecules, extracellular matrix proteins, and signaling molecules to regulate proper neuronal positioning and axonal pathfinding. Dysregulation of CNTNAP2 expression or function can impact brain development and neural connectivity.

CNTNAP2

LRRC42 (Leucine-rich repeat-containing protein 42): LRRC42 is a gene that encodes a protein belonging to the leucine-rich repeat (LRR) family, characterized by repeating sequences rich in leucine residues. Primarily located in the cytoplasm or on the cell membrane, LRRC42 is involved in cellular processes such as signal transduction, protein-protein interactions, and cell adhesion. Its LRR domains act as interaction interfaces, allowing LRRC42 to bind specific partner proteins and engage in various cellular pathways.

LRRC42

KIAA1109: KIAA1109 is a gene linked to various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease. Although its precise function is not completely understood, it is believed to play a crucial role in immune regulation and the body’s inflammatory responses. Researching KIAA1109 is essential for understanding the genetic foundations of autoimmune disorders and for supporting the development of targeted treatments.

KIAA1109

Buckwheat intolerance is a condition where the body has difficulty digesting buckwheat, causing digestive symptoms. Unlike a buckwheat allergy, which triggers an immune response and can lead to severe reactions, intolerance mainly results in gastrointestinal discomfort.

UBLCP1 (Ubiquitin-Like Domain Containing CTD Phosphatase 1): UBLCP1 is a protein that indicates the activity of a phosphatase involved in regulating RNA polymerase II, a key enzyme in transcription. UBLCP1 plays a vital role in dephosphorylating the C-terminal domain of RNA polymerase II, affecting gene expression and influencing various cellular processes and disease mechanisms.

UBLCP1

POC1B (POC1 Centriolar Protein B): POC1B is a protein that plays a key role in the structure and function of centrioles, essential cellular components. Centrioles are critical for cell division, organization of the microtubule cytoskeleton, and the formation of cilia and flagella. POC1B contributes to centriole assembly and maintenance, supporting accurate chromosome segregation and proper cell cycle progression. It also plays a vital role in ciliogenesis, which is important for processes such as fluid movement in the respiratory tract, sperm motility, and sensory signal transduction.

POC1B

PPARG (Peroxisome Proliferator-Activated Receptor Gamma): PPARG is a nuclear receptor that regulates the expression of genes involved in fatty acid storage, glucose metabolism, and adipocyte differentiation. It plays a central role in insulin sensitivity and is targeted by thiazolidinediones, a class of antidiabetic drugs. Its involvement in metabolic pathways makes it an important gene in the study of obesity, diabetes, and cardiovascular disease.

PPARG

KCNJ3 (Potassium Voltage-Gated Channel Subfamily J Member 3): KCNJ3, also known as GIRK1 (G protein-activated inwardly rectifying potassium channel 1), is a gene that encodes a protein involved in regulating neuronal excitability and heart rate. By controlling potassium ion flow, KCNJ3 helps stabilize the resting membrane potential and modulate action potentials in neurons and cardiac muscle cells. Dysregulation of KCNJ3 may contribute to neurological disorders, such as epilepsy and mood disorders, as well as cardiovascular diseases.

KCNJ3

KRT72 (Keratin 72): KRT72 is a gene that encodes a type II keratin, a key component of the cytoskeletal structure in epithelial cells. It plays a crucial role in maintaining the structural integrity and proper function of hair follicles. Mutations in KRT72 are frequently associated with hair disorders, underscoring its vital role in hair formation and maintenance.

KRT72

ASB13 is a member of the ASB protein family, characterized by ankyrin repeat domains and a SOCS box domain. It plays a crucial role in regulating protein degradation and signal transduction. As an E3 ubiquitin ligase, ASB13 aids in tagging and breaking down specific protein targets. Its SOCS box domain interacts with components of the ubiquitin–proteasome system, including E2 enzymes and Cullin-RING ligase complexes, to guide targeted protein turnover.

ASB13

SERPINE2 (Serpin Family E Member 2): SERPINE2 is a serine protease inhibitor, also known as protease nexin-1, that plays a key role in regulating proteolytic pathways in the body. It is involved in tissue remodeling, fibrinolysis, and neuronal growth, and helps inhibit enzymes such as thrombin and urokinase-type plasminogen activator, which are important for blood clotting and tissue repair. Dysregulation of SERPINE2 has been linked to cardiovascular and neurological disorders, highlighting its importance in maintaining tissue integrity and function.

SERPINE2

SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha): SCNN1A is a gene that encodes the alpha subunit of the epithelial sodium channel (ENaC), which regulates sodium balance and fluid homeostasis in tissues such as the lungs, kidneys, and colon. This subunit is essential for ENaC’s assembly, localization, and function, enabling sodium absorption that supports blood pressure, fluid volume, and electrolyte balance. Mutations in SCNN1A can alter channel activity and are linked to conditions such as pseudohypoaldosteronism type 1 (PHA1), a disorder affecting salt regulation.

SCNN1A

MYC (MYC Proto-Oncogene, BHLH Transcription Factor): MYC is a well-known oncogene that plays a central role in cell cycle regulation, apoptosis, and cellular transformation. As a transcription factor, it controls the expression of numerous genes involved in key cellular processes. Overexpression of MYC is common in many cancers, making it a major focus of oncology research. Understanding MYC regulation and its pathways is critical for developing targeted cancer therapies, as its dysregulation contributes to tumor growth, progression, and treatment resistance.

Lime intolerance refers to a sensitivity some people have to lime, a citrus fruit known for its tart flavor. While lime is widely used in various dishes and beverages for its refreshing taste and health benefits, intolerance can lead to digestive issues and other negative reactions in certain individuals.

Lime

NTM (Neurotrimin): NTM is a neural cell adhesion molecule involved in forming neural networks. It plays a key role in neural development, especially in neurite outgrowth and synaptic plasticity. Research on NTM helps to better understand the mechanisms behind neural development and its potential connections to neurodevelopmental disorders.

SOS2 (Son of Sevenless Homolog 2): SOS2 is a protein involved in cell signaling and the activation of the Ras/MAPK pathway. It plays a key role as a mediator in cellular responses to growth factors, cytokines, and extracellular signals, contributing to diverse physiological processes and cellular functions.

SOS2

CDK17 (Cyclin-dependent kinase 17): CDK17 is a nuclear enzyme that belongs to the cyclin-dependent kinase family, essential for regulating the cell cycle, controlling transcription, and cellular differentiation. As a serine/threonine protein kinase, CDK17 phosphorylates target proteins to regulate their activity. It plays a crucial role in driving cell cycle progression, especially in promoting the transition from the G1 phase to the S phase, where DNA replication occurs.

CDK17

Scallop intolerance is a condition that affects the ability to consume scallops — sweet, delicate shellfish popular in seafood cuisine — without adverse reactions. While scallops are enjoyed for their flavor and nutritional value, intolerance can cause digestive discomfort and other symptoms in sensitive individuals.

Scallop

JUP (Junction Plakoglobin): JUP is a gene that produces plakoglobin, a protein located in cell-cell junctions such as desmosomes and adherens junctions. Plakoglobin is essential for maintaining the structural integrity of tissues, particularly in the skin and heart.

SOX2, short for SRY (Sex Determining Region Y)-Box 2, is a crucial transcription factor involved in embryonic development, stem cell pluripotency, and tissue homeostasis. Primarily located in the cell nucleus, SOX2 regulates gene expression by binding to specific DNA sequences and controlling the activity of target genes. It plays a key role in maintaining stem cell pluripotency and self-renewal, working in concert with other transcription factors such as OCT4 and NANOG to form a core network that sustains the undifferentiated state of embryonic stem cells.

SOX2

PROX1 (Prospero Homeobox 1): PROX1 is a transcription factor that regulates gene expression and is involved in essential developmental processes. It plays a key role in lymphatic vessel formation, liver development, and determining cell fate. In the lymphatic system, PROX1 serves as the master regulator of lymphatic endothelial cell differentiation and maintenance.

PROX1

LARP4B (La-Related Protein 4B): LARP4B is part of the La-related protein (LARP) family, which is involved in regulating RNA stability and translation. Although the specific roles of LARP4B are still under investigation, LARPs generally play a role in post-transcriptional gene regulation by influencing mRNA stability, translation, and cell growth. Studying LARP4B may offer valuable insights into gene expression control and its connections to diseases related to RNA dysregulation.

LARP4B

Water metals are metallic elements present in water, either dissolved or suspended as particles. Common examples include iron, copper, lead, arsenic, and mercury. They can originate from natural sources such as soil and rock formations or from human activities like industrial discharge, plumbing corrosion, and agricultural runoff.

Water Metals

PDZD2 (PDZ Domain Containing 2): PDZD2 is a multi-PDZ domain protein that helps organize protein complexes at the cell membrane, facilitating signal transduction and cellular communication. It participates in various cellular functions, including synaptic signaling in neurons, and its dysregulation may be linked to neurological disorders.

PDZD2

Minerals

Strontium is a trace mineral that, like calcium, supports bone strength and may help reduce the risk of osteoporosis. It naturally occurs in foods such as seafood, whole grains, and vegetables. While beneficial in small amounts, excessive intake can hinder calcium absorption, emphasizing the importance of maintaining proper mineral balance.

Strontium

FAM53A (Family With Sequence Similarity 53 Member A): FAM53A is involved in regulating cell proliferation and may have a role in cell development and differentiation. Although its function has been less studied, it appears to be essential for normal cellular functions and possibly for maintaining cell integrity. Ongoing research seeks to clarify its exact roles and how disruptions in its regulation may affect disease processes, such as cancer and developmental disorders.

FAM53A

KAT2B (Lysine Acetyltransferase 2B): KAT2B, also known as PCAF, encodes an enzyme involved in histone acetylation, a process essential for regulating gene expression. It contributes to DNA repair, cell cycle control, and apoptosis, and plays a key role in transcription regulation and chromatin remodeling. KAT2B has been linked to cancer development and certain developmental disorders.

KAT2B

MROH2A (Maestro Heat-Like Repeat Family Member 2A): MROH2A is a protein that belongs to a family characterized by maestro heat-like repeats, which are believed to play a role in lipid metabolic processes. Although its exact functions are not yet fully understood, MROH2A may be involved in cellular lipid metabolism and could have significance for metabolic disorders. Investigating its role could offer valuable insights into metabolic regulation and mechanisms related to lipid-associated diseases.

MROH2A

MAP7 (Microtubule-Associated Protein 7): MAP7 is a protein that helps stabilize microtubules and interacts with motor proteins. It affects cell movement and organization and is involved in processes such as mitosis and intracellular transport. MAP7 is essential for maintaining cellular structure and dynamics.

MAP7

RSU1 (Ras Suppressor Protein 1): RSU1 is a protein that interacts with key signaling molecules, including Ras. It plays a vital role in regulating cell adhesion and motility, contributing to multiple cell signaling pathways. RSU1 may also be involved in cancer progression and metastasis.

RSU1

XYLT1 (Xylosyltransferase 1): XYLT1 is an enzyme involved in the biosynthesis of proteoglycans, essential components of the extracellular matrix. It catalyzes the addition of xylose to specific serine residues, a crucial step in forming connective tissues. Mutations in XYLT1 can lead to skeletal and connective tissue disorders, highlighting its vital role in tissue development and maintenance.

XYLT1

GJA10 (Gap Junction Protein Alpha 10): GJA10 is a gene that encodes a connexin protein forming gap junction channels for the direct exchange of ions and small molecules between cells. This communication supports tissue homeostasis and coordinated cell activity. In the eye, GJA10 helps maintain lens transparency and function, and mutations have been linked to cataracts and other vision disorders.

GJA10

CCR3 (C-C Motif Chemokine Receptor 3): CCR3 is a receptor involved in recruiting and activating eosinophils, basophils, and T cells, playing a crucial role in inflammatory responses and allergic disease pathology. It acts as the primary receptor for eotaxin, a chemokine that drives eosinophilic inflammation seen in conditions like asthma and allergic rhinitis. Dysregulation of CCR3 signaling can exacerbate allergic and inflammatory conditions, making it a potential target for therapeutic intervention.

CCR3

SETD7 (SET Domain Containing 7, Lysine Methyltransferase): SETD7 is a gene involved in epigenetic regulation that encodes an enzyme responsible for methylating histone proteins. This modification is crucial for controlling gene expression. Dysregulation of SETD7 activity has been associated with various diseases, including cancer and cardiovascular disorders.

SETD7

MAF (MAF BZIP Transcription Factor): MAF is a gene that encodes a transcription factor involved in the development and differentiation of various tissues, including the eye lens and pancreatic beta cells. It regulates gene expression and influences cell fate decisions. Mutations in MAF have been linked to developmental disorders and certain diseases.

BORCS7 (BLOC-1 Related Complex Subunit 7): BORCS7 is a component of the BLOC-1 (Biogenesis of Lysosome-related Organelles Complex-1). It plays a crucial role in the formation of lysosome-related organelles, such as melanosomes in melanocytes. Dysfunction in BORCS7 may impact pigmentation and neurological functions.

BORCS7

LRRC6 (Leucine-Rich Repeat-Containing Protein 6): LRRC6 is a gene that encodes a protein involved in the structure of cilia within cells. Cilia play a crucial role in cell movement and signaling. Mutations in LRRC6 can result in ciliopathies, a group of genetic disorders characterized by ciliary dysfunction and a variety of clinical symptoms.

LRRC6

ETS2 (ETS Proto-Oncogene 2, Transcription Factor): ETS2 is a gene that encodes a transcription factor from the ETS family. Transcription factors such as ETS2 regulate the expression of specific target genes by binding to particular DNA sequences. ETS2 plays crucial roles in cellular processes including cell proliferation, differentiation, and development. Dysregulation of ETS2 has been associated with cancer and developmental disorders.

ETS2

LEMD3 (Lamin-Associated Polypeptide 2, Isoform 1): LEMD3 is a gene that encodes a protein linked to the nuclear envelope, playing a role in the structure and organization of the nucleus. Mutations in LEMD3 have been associated with Buschke-Ollendorff syndrome, a rare genetic disorder affecting bone and skin.

LEMD3

SH2B3 (SH2B Adaptor Protein 3): SH2B3 (SH2B Adaptor Protein 3) is an adaptor protein that negatively regulates cytokine signaling in hematopoietic cells. It plays a key role in maintaining hematopoietic stem cell homeostasis and controlling immune responses. Mutations in SH2B3 are linked to various hematologic disorders, including myeloproliferative neoplasms and autoimmune diseases, highlighting its importance in blood cell development and immune regulation.

SH2B3

FGFR2 (Fibroblast Growth Factor Receptor 2): FGFR2 is a receptor that binds to fibroblast growth factors and plays a key role in cell growth, differentiation, and tissue repair. It is essential for normal development, and mutations in FGFR2 are associated with several developmental disorders such as craniosynostosis and skeletal dysplasia, as well as being involved in certain cancers.

FGFR2

EIF4A1, also known as Eukaryotic Translation Initiation Factor 4A1, is a highly conserved RNA helicase enzyme that plays a crucial role in the initiation of translation, the essential process of protein synthesis. As a member of the DEAD-box RNA helicase family, EIF4A1 is responsible for unwinding secondary structures in mRNA, enabling ribosomes to access the initiation codon and begin protein production. It functions as part of the eukaryotic translation initiation complex, working alongside other initiation factors to bind and scan the 5' untranslated region (UTR) of mRNA.

EIF4A1

PAX5, also known as Paired Box 5, is a transcription factor that plays a crucial role in B-cell development and differentiation. It is part of the PAX family of transcription factors, characterized by a conserved paired box domain involved in DNA binding and protein interactions. PAX5 is vital for directing B-cell lineage commitment during hematopoiesis and is expressed in progenitor cells that are destined to become B cells, supporting their development from hematopoietic stem cells.

PAX5

COG1 (Component Of Oligomeric Golgi Complex 1): COG1 is a part of the COG complex, a vital element for normal Golgi function and protein trafficking within the cell. Proper functioning of COG1 is crucial for glycoprotein processing, and mutations in COG1 can impair Golgi activity, resulting in congenital disorders of glycosylation—a group of metabolic conditions that cause various developmental issues.

COG1

PRB2 (Proline-Rich Protein BstNI Subfamily 2): PRB2 is a protein involved in oral and salivary biology. It plays a key role in forming the dental pellicle and protecting the oral mucosa. As a member of the proline-rich protein family, PRB2 is essential for maintaining oral health and defending against dental caries and other oral diseases.

PRB2

FOXO3 (Forkhead Box O3): FOXO3 is a transcription factor that plays a key role in regulating genes involved in cell cycle arrest, DNA repair, and apoptosis. It is an important player in the study of longevity and age-related diseases, influencing pathways that affect the aging process. In aging research, FOXO3 stands out as a central factor, with scientists working to understand its role in the complex mechanisms of life and aging.

FOXO3

C-reactive protein (CRP) testing measures the amount of CRP in the blood, a marker that indicates inflammation in the body. Elevated CRP levels can signal acute inflammation, infections, or chronic conditions such as rheumatoid arthritis and heart disease. This test is commonly used to diagnose and monitor inflammatory conditions, detect flare-ups, and assess cardiovascular risk. Regular CRP testing helps guide treatment decisions and evaluate the effectiveness of therapies in reducing inflammation.

Total IgE testing measures the overall level of Immunoglobulin E (IgE) antibodies in the blood, which are produced in response to allergens. Elevated levels may indicate increased allergic sensitivity but do not identify specific allergens.

Total IgE

Parasites Worms

Enterocytozoon and Encephalitozoon species are microsporidia—spore-forming single-celled parasites that can infect humans. They can cause gastrointestinal and systemic diseases, especially in people with weakened immune systems. Symptoms vary depending on the site of infection but commonly include diarrhea, weight loss, and fatigue.

Enterocytozoon spp. / Encephalitozoon spp.

NR3C2, also known as Nuclear Receptor Subfamily 3 Group C Member 2 or mineralocorticoid receptor (MR), is a nuclear receptor protein that plays a key role in regulating electrolyte balance and blood pressure. It functions as a ligand-activated transcription factor primarily located in the cytoplasm of target cells. When bound to mineralocorticoid hormones such as aldosterone, NR3C2 undergoes a conformational change and translocates to the nucleus to exert its effects. Its primary function includes regulating sodium and potassium ion transport in the kidney, colon, and salivary glands.

NR3C2

MECOM (MDS1 and EVI1 Complex Locus): MECOM is a transcriptional regulator involved in hematopoiesis and the development of certain cancers, particularly myeloid leukemia. It encodes EVI1, a protein that plays a role in gene regulation, cell proliferation, and cell differentiation.

MECOM

IL12B (Interleukin 12B): IL12B is a gene that encodes the p40 subunit of interleukin-12 (IL-12), a cytokine involved in immune responses. IL-12 plays a key role in activating the immune system by promoting the production of interferon-gamma (IFN-γ) and stimulating the activity of T cells and natural killer (NK) cells to fight infections and tumors.

IL12B

Pineapple intolerance refers to the body's difficulty digesting certain components of pineapple fruit, resulting in adverse reactions or symptoms after consumption. Unlike pineapple allergies, it does not involve the immune system's response to specific proteins but is related to digestive sensitivity.

Salmon roe/caviar

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