POLR3A (RNA Polymerase III Subunit A): POLR3A is a crucial subunit of RNA polymerase III, the enzyme responsible for producing small RNAs such as tRNAs, 5S rRNA, and other non-coding RNAs. It plays a vital role in transcribing genes required for protein synthesis and other essential cellular functions. Mutations in POLR3A have been linked to neurological disorders and developmental abnormalities, underscoring its critical significance for cellular function and human health.