Indole-3-acetic acid is a tryptophan-derived metabolite produced by intestinal bacteria. It plays a role in gut–liver communication and can affect oxidative stress and intestinal permeability. Elevated IAA levels may indicate dysbiosis, increased bacterial tryptophan metabolism, or altered liver detoxification pathways. Normal levels suggest balanced gut microbiota activity and effective metabolic clearance.
High IAA levels may indicate an imbalance in gut microbiota, excessive bacterial metabolism of tryptophan, or decreased liver detoxification capacity. Elevated levels can sometimes be associated with oxidative stress or increased intestinal permeability.
Testing IAA can provide valuable insights for individuals experiencing gut-related symptoms, such as bloating or food sensitivities, or those suspected of having liver overload. It may also be helpful in evaluating tryptophan metabolism in people dealing with fatigue, inflammation, or metabolic imbalances.
IAA is produced by gut bacteria from dietary tryptophan. Its levels depend on microbial diversity, diet composition, and liver function. Dysbiosis, poor digestion, or impaired detoxification can all increase IAA.
Yes. Supporting a balanced gut microbiota through prebiotic fibers, antioxidants, and reduced exposure to toxins can help regulate IAA production. Promoting liver detoxification and maintaining a nutrient-dense, anti-inflammatory diet also support healthy levels.