Hippuric acid is a metabolic compound produced in the liver through the conjugation of benzoic acid with glycine. It indicates both detoxification capacity and microbial activity in the gut. Elevated levels may suggest increased microbial fermentation, exposure to certain food additives, or an active detoxification response. Low concentrations can result from reduced liver conjugation capacity or decreased microbial production of precursors.
Elevated hippuric acid levels may indicate increased microbial fermentation, exposure to food additives (such as benzoates), or an active detoxification response. Low levels can result from reduced liver conjugation capacity or insufficient microbial production of precursors.
Testing hippuric acid can be useful for people showing signs of liver overload, chemical sensitivity, or digestive imbalance. It can also help assess detoxification effectiveness and microbial activity in the gut.
Levels are influenced by both gut microbial metabolism and liver conjugation processes. Diet, toxin exposure, microbial composition, and nutrient availability (particularly glycine) all play key roles in determining hippuric acid concentration.
Yes. Supporting liver detoxification with proper hydration, antioxidant intake, and sufficient glycine and B vitamins can promote healthy conjugation. Maintaining gut microbial balance through fiber-rich foods and reducing exposure to artificial additives also helps maintain optimal levels.