ADMA (Asymmetric Dimethylarginine)
ADMA is a naturally occurring inhibitor of nitric oxide synthase (NOS), the enzyme that produces nitric oxide (NO), a crucial molecule for vascular tone and endothelial function. Elevated ADMA levels can decrease nitric oxide availability, potentially impacting blood vessel dilation and circulation. Higher concentrations have been linked to endothelial dysfunction and impaired regulation of blood flow. Low or balanced ADMA levels generally indicate healthy nitric oxide production and proper vascular function.
Description
High ADMA levels may not cause direct symptoms, but they can contribute to reduced nitric oxide availability, leading to poor blood vessel dilation. Over time, this may manifest as fatigue, cold extremities, elevated blood pressure, or signs of endothelial dysfunction.
Testing ADMA can be especially helpful for people with cardiovascular risk factors such as high blood pressure, high cholesterol, diabetes, obesity, or metabolic syndrome. It may also be beneficial for those experiencing symptoms of poor circulation or unexplained chronic fatigue.
ADMA levels are affected by oxidative stress, inflammation, and impaired methylation or kidney function. Lifestyle factors such as an unhealthy diet, smoking, and lack of physical activity can also increase ADMA.
In many cases, yes. Reducing oxidative stress, supporting endothelial health, and maintaining good kidney and methylation function can help normalize ADMA levels. Nutrients like L-arginine, L-citrulline, folate, and vitamin B12 are involved in pathways related to nitric oxide synthesis and methylation balance.
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